Area Coordinator in Biology
Associate Professor of Biology
Office 3130 Mesa Building
Phone (432) 552-2270
E-mail: henderson_d@utpb.edu
Degree
Ph.D., University of Texas, Austin, 1993
Education
1987 - 1993 Ph.D. in Microbiology, University of Texas at Austin
1983 - 1986 Special student in Natural Sciences, University of Texas at Austin
1970 - 1974 B.A. in English and Drama, Fairmont State College, Fairmont, WV
Professional Work Experience
2002 to present Associate Professor, Department of Science and Mathematics, University of Texas of the Permian Basin
Courses taught:
Human Genetics, Genetics, Genetics Lab, Molecular Genetics (graduate), Molecular Genetics Laboratory (graduate),
Immunology (undergradate/graduate), Virology (undergraduate and graduate), Microbiology, Microbiology Laboratory,
Biology I, Biology I Laboratory, Biology II Laboratory, Bacteriology (graduate), Nutrition
1996 -2002 Assistant Professor, Dept. of Science and Mathematics, University of Texas of the Permian Basin
1994 -1996 Postdoctoral Fellow, Pharmacy, University of Texas at Austin
1993-1994 Postdoctoral Fellow, Microbiology, University of Texas at Austin
1990 - 1993 Research Assistant, University of Texas at Austin
1987 - 1990 Teaching Assistant, University of Texas at Austin (eight semesters)
Courses taught: Introductory Microbiology Lab, Public Health Bacteriology Lab
1986 - 1987 Administrative Assistant, College of Pharmacy, University of Texas
1981 - 1983 Writer/Editor, Food and Drug Administration, Washington, DC
1978 - 1981 Editorial Assistant, Food and Drug Administration, Washington, DC
1976 - 1978 Customer Service Representative, Virginia Electric/Power Company, Alexandria, VA
1975 - 1976 Production and Personnel Assistant, A & P Printing Company, Fairmont, WV
1974 - 1975 High School English Teacher, Tucker County Board of Education, Parsons, WV
Scholarly Works
Funded External Grants
Bacterial heme transport and hemoglobin expression. AREA NIH Grant with the National Heart Lung and Blood Institute.$209,000, June 1, 2005-May 31, 2008.
Patent Application
Olson, J. S. and D.P. Henderson. 2006. Increasing Hemoglobin Production in E. coli by Co-Expression with the Heme Utilization Genes (Hug) From Plesiomonas shigelloides and other Intestinal Pathogens. Rejected on technicality..
Refereed Papers
Villarreal, DM, CL Phillips, AM Kelley, S Villarreal, P Hernandez, JL Olson and DP Henderson. 2008. Enhancing recombinant hemoglobin production in Escherichia coli BL21(DE3) containing the Plesiomonas shigelloides heme transport system. Appl and Environ Microbiol. 74:2854-5856.
Graves, PE, D.P. Henderson, M. Horstman, B. Solomon, and Olson, J.S.2008. Enhancing stability and expression of recombinant human hemoglobin in E. coli: progress in the development of recombinant HBOC Source. Biochemica Biophys Acta. Doi: 10.1016/j.bbapap.2008.04.012.
Oldham, AL, T Brandt, DP Henderson (2008) Plesiomonas shigelloides hugZ encodes an iron-regulated heme binding protein required for heme iron utlization. Can J Microbio 54:97-102.
Henderson, DP, Wyckoff, EE, Rashidi, CE, Verlei, H and AL Oldham. (2001) Characterization of the Plesiomonas shigelloides genes encoding the heme iron utilization system. J Bacteriol 183: 2715-2723.
O’Malley, SM, Mouton, SL, Ochinno, DA, Deanda, MT, Rahsidi, JR, Fuson, KL, Rashidi, CE, Mora, MY, Payne, SM and DP Henderson. (1999) A comparison of the heme iron utilization systems of pathogenic Vibrios, J Bacteriol 181:3594-3598.
Occhino, D, Wyckoff, E, Henderson, DP, Wrona, TJ, and SM Payne. (1998) Vibrio cholerae iron transport: haem transport genes are linked to one of two sets of tonB, exbB, exbD genes. Mol Micro 29:1493-1507.
Henderson, D P and LH Hurley (1995) Molecular struggle for transcriptional control. Nature Medicine 1:525-527.
Henderson, DP and LH Hurley (1995) Specific targeting of protein-DNA complexes by DNA reactive drugs (+)-CC-1065) and pluramycins. J Molecular Recognition 9:75-87.
Henderson, DP and SM Payne (1994) Role of the heme iron utilization system in the virulence of Vibrio cholerae. Infect Immun 62:5120-5125.
Henderson, DP and SM Payne (1994) Characterization of the Vibrio cholerae outer membrane heme transport protein HutA: sequence of the gene, regulation of expression, homology to the family of TonB-dependent proteins. J Bacteriol 176:3269-3277.
Henderson, DP and SM Payne (1993) Cloning and characterization of the Vibrio cholerae genes encoding the utilization of iron from hemin and hemoglobin. Mol Micro 7:461-469.
Chapters in Books
Payne, SM and DP Henderson (1994) Characterization of the Vibrio cholerae heme iron transport system and its role in pathogenesis, in Molecular Mechanisms of Bacterial Virulence, C.I. Kada and J.H. Crosa (eds.) pp. 173-184, Doudrecht:Kleuer.
Conference Proceedings
C.L. Phillips, D.M. Villarreal, S. Villarreal, A.M. Kelley, J.S. Olson, and D.P. Henderson. 2007. Reconstituting the Plesiomonas shigelloides or the Vibrio cholerae heme transport system in Escherichia coli to increase hemoglobin production. Annual Meeting of the American Society for Microbiology, Toronto (poster).
Phillips, C.L., Gonzales, C.I., Villarreal, D.M., Olson, J.S., and D. P. Henderson (2006) Testing Hemoglobin Production in Three Strains of Escherichia coli Transformed with a Recombinant Plasmid Containing the Human Hemoglobin Genes and shuA, the Shigella dysenteriae Heme Receptor Gene. Annual Meeting of the American Society for Microbiology, Orlando (poster)
Villarreal, D.M, Olson, J.S., and D. P. Henderson, 2006. Reconstituting the Plesiomonas shigelloides Heme Transport System in Escherichia coli to Increase Production of Hemoglobin. Annual Meeting of the American Society for Microbiology, Orlando. (poster)
Gonzales, C. and D.P. Henderson. 2005. Using a bacterial heme transport system to help over express hemoglobin for use as a blood substitute. LSAMP Conference, Richardson, TX. Best student performance.
Oldham, A.L., Ingraham, J. and D.P. Henderson. 2004. Analysis of hugZ, a heme utilization gene in Plesiomonas shigelloides. Annual Meeting of the American Society for Microbiology, New Orleans. (poster)
Graves, P.E., Henderson, D.P., and J.S. Olson. 2003. Increasing hemoglobin expression using heme transport system proteins from Plesiomonas shigelloides. Alliances for Graduate Education and the Professoriate, Rice University (poster).
Villaloboz, A.A. and D.P. Henderson. 2003. Using Escherichia coli containing the Plesiomonas shigelloides heme transport system to increase myoglobin expression. Annual Meeting of the American Society for Microbiology, Washington, DC. (poster)
Oldham, A.L. and D.P. Henderson. 2003. Analysis of the Plesiomonas shigelloides heme iron utilization gene hugWXZ, Annual Meeting of the American Society for Microbiology, Washington, DC. (poster)
Villaloboz, A.A. and D.P. Henderson. 2002. Increasing myoglobin expression in Escherichia coli: Furthering blood substitute research. UTPB Research Forum. Best student presentation.
Villaloboz, A.A. and D.P. Henderson. 2002. Increasing myoglobin expression in Escherichia coli: Furthering blood substitute research. LSAMP conference in El Paso, TX
Oldham. A.L. and D.P. Henderson. 2002. Regulation of the Plesiomonas shigelloides heme receptor gene hugA. UTPB Undergraduate Research Seminar, Best Student Presentation
Oldham, A.L. and D.P. Henderson. 2002. Increasing production of unstable myoglobin protein by exploiting the heme biosynthesis pathway: Initial work on development of blood substitute made from hemoglobin. LSAMP conference in El Paso, TX
Henderson, DP, Willis, JK, Hodnett, J, Etheridege, K, Villaloboz, AA, and AL Oldham. (2002) Analysis of the role of Plesiomonas shigelloides hugWXZ in heme iron utilization. Annual Meeting of American Society for Microbiology, Salt Lake City (poster).
Henderson, DP, Wyckoff, EE, Oldham, AL, Willis, JK and MJ Edwards. (2001) Functional analysis of the heme iron utilization genes of Plesiomonas shigelloides and isolation of genes encoding periplasmic and inner membrane permeases. Annual Meeting of American Society for Microbiology, Orlando (poster).
Verlei, H. and D.P. Henderson. (2000) The TonB system of Plesiomonas shigelloides. UTPB Undergraduate Research Seminar, Best Student Presentation.
Henderson, DP, Wyckoff, EE, and H Verlei (2000) Characterization of the heme iron utilization system in Plesiomonas shigelloides. Annual Meeting of American Society for Microbiology, Los Angeles (poster)
Henderson, DP, Stoebner, JA, Wyckoff, E and SM Payne (1999) Characterization of the heme iron utilization system in Plesiomonas shigelloides. Annual Meeting of American Society for Microbiology, Chicago (poster)
O’Malley, SM, Mouton, SL, Ochinno, DA, Fuson, KL, Deanda, MT, Rashidi, JR, Mora, MY and DP Henderson (1998) A comparison of the heme iron utilization genes of V. cholerae with DNA of other Vibrio species and the isolation of a hutA-like gene from V. parahaemolyticus that functions interchangeably with the V. cholerae hutA. Annual Meeting of American Society for Microbiology, Atlanta (poster).
Henderson, DP and LH Hurley (1995) Establishment of a system to determine the effect of (+)-CC-1065-induced bending on the level of transcription from a modified SV-40 early promoter. Buffalo Medicinal Chemistry Symposium, Buffalo, N.Y. (poster)
Henderson, DP and SM Payne (1994) Role of TonB in Vibrio cholerae heme iron transport. Annual Meeting, American Society for Microbiology, Las Vegas (oral presentation).
Henderson, DP and SM Payne (1993) The heme transport system of Vibrio cholerae. Annual Meeting, Texas Branch of American Society for Microbiology, Austin (oral presentation)
Henderson, DP and SM Payne (1992) Utilization of hemin as an iron source by Vibrio cholerae requires a 77 kDa iron-regulated outer membrane protein. Annual Meeting, American Society for Microbiology, New Orleans (poster).
Henderson, DP and SM Payne (1991) Utilization of hemin as an iron source by Vibrio cholerae. Annual Meeting, Texas Branch of American Society for Microbiology, Austin (oral presentation).
Henderson, DP and SM Payne (1991) Utilization of hemin as an iron source by Vibrio cholerae requires a 26 kDa inner membrane protein. Annual Meeting, American Society for Microbiology, Dallas (oral presentation).
Henderson, DP and SM Payne (1990) A 20 kDa protein is associated with heme utilization in Vibrio cholerae. Annual Meeting, Texas Branch of American Society for Microbiology, Austin (oral presentation).
Professional Service
2007-present Graduate Council
2007 Chair, Search Committee for Biology Assistant professor
2006-present University Biosafety Committee
2005-present Institutional effectiveness plan for undergradaute biology
1997-present Health Professions Advisory Committee
1997-present Institutional Animal Care and Use Committee
1997-present Judge in Regional Science Fair
2006-present Ad Hoc Committee on Standards for Tenure and Promotion
2001-2005 Three search committees for Assistant Professors in Biology
Search Committee for Academic Advisor for Advising Center
Search Committee for Lecturer for Biology
Search Committee for Biomechanics Faculty for Kinesiology
Seach Committee for Chemistry Assistant Professor and Lecturer
2004-2005 Area Coordinator, Biology
2003-2004 Chairman, College of Arts and Sciences Tenure and Promotion Committee
2001-2003 Chairman, Graduate Council (began term September, 2001; Chairman from Jan, 2002 to
2003)
2003 Chairman, Ad Hoc Nominating Committee for Faculty Senate
2002-2003 College of Arts and Sciences Tenure and Promotion Committee
1997-2005 Chairman, Institutional Animal Use and Care Committee
1998-2000 Chairman, College of Arts and Sciences Curriculum Committee (member of committee 1997-2001)
1997-2000 Chairman, Lab Policy and Safety Committee (member 1997-2001)
2000-2001 Academic Affairs Committee
1998 SACS Committee on Administration and Organization
1998 Actor in University production of All in the Timing
1997 University Budget Committee
Served on 19 thesis committees (eight as chair)
Professional Honors and Other Professional Activites
2007 University Research Award
2004 Finalist, UTPB Teaching Excellence Award,
2003 Reviewer for NIH Study Section BM-1 to review intestinal pathogen grant proposals
2001 Reviewer for the journal Molecular Microbiology
1990-present Member of the American Society for Microbiology
2001/1998/1997 Professional Development Grants, University of Texas, Permian Basin
Using bacterial heme transport system to increase yields of myoglobin and/or
hemoglobin for use as a blood substitute (2001) ($1000)
Genetic characterization of the heme iron utilization system in pathogenic Vibrios
(1998) ($700)
Characterization of the heme iron utilization system of Vibrio parahaemolyticus:
genetics and role in virulence (1997) ($2000).
2001-2003 Sponsored Projects Development Grant $43,000
1997-2003 Six Alliance for Minority Participation Grants totalling $5,500 for lab supplies and $36,400 for salary for six undergraduate students (two students received two one-year appointments)
2001 Project InterCon Grant ($1000 in lab supplies and $2000 for salary for two high school students)
1998 Golden Windmill Award for research, University of Texas, Permian Basin Study of the heme iron utilization system of pathogenic Vibrios and of the intestinal
pathogen Plesiomonas shigelloides ($1000).
1991 S. Edward Sulkin Award (Best student presentation in Medical Microbiology at Annual Meeting of Texas Branch of the American Society for Microbiology)
1990 - 1991 University Fellowship, University of Texas at Austin
1990 L.J. Barry Award (For excellence in Medical Microbiology)
Community Service Awards
1999 Nominated for W.D. Noel Outstanding Volunteer Award for volunteer work at Safe Place
1996 Community Service Award, Battered Women’s Center, Austin, TX.
1995 Outstanding Speakers’ Bureau Volunteer, Battered Women’s Center, Austin, TX.
Community Service Activities
2001 Advisor to Pathways to a Better Life, a non-profit organization that promotes anger management and positive change for men or women who batter their partners.
1999-2000 Member of Project Adam Advisory Committee
1999-2000 Member, Board of Directors of the Permian Basin Center for Battered Women and Their Children
1998-2000 Co-facilitator in Project ADAM (20 week program to help batterers change their behavior)
4901 E. University . Odessa, Texas 79762 . (432) 552-2020